Alessandro graduated in Biology obtaining his Bachelor’s Degree in 2009 and a Master’s Degree in Molecular Evolution in 2013 at the University of Siena. He worked for six months in a big company in the field of Life Sciences. In November 2013, he won a competition for PhD students in Biochemistry and Molecular Biology at the University of Siena. In the first year, he worked on a project of Influenza Viral Growth in cell culture. In the summer 2015, he spent five months at the Influenza Centre in Bergen, Norway, under the direction of Professor Rebecca Jane Cox, studying the field of validation of new serological assays for IgA and IgG detection. Currently, he is working as a Scientist on the development and standardization of serological assays for IgA and IgG detection in Nasal, Saliva and Serum samples and for anti-Neuraminidase antibody detection.
In 2007, Francesco earned his BSc at the University of Milan by carrying out a thesis work aimed at understanding the mechanisms of protein degradation in S. cerevisae yeast. In 2009, at the University of Rome “La Sapienza”, he obtained a MSc in Genetics and Molecular Biology, writing a thesis on the role of human microRNA-140 in the cleft palate. From 2010 to 2014, he was a research assistant in biochemistry and molecular biology at the Max Planck Institute for Developmental Biology in Tuebingen (Germany) where he was interested in the mechanisms of RNA degradation in eukaryotic cells. From 2014 to 2016, he was a research technician at the Neuroscience Department of the Italian Institute of Technology in Genoa, managing laboratories and supporting the research. In 2016, he obtained a master in Integrated Management Systems: Quality (ISO:19001), Environment (ISO:14001) and Safety (ISO:45001). From 2016 to 2019, as a member of the Health and Safety Office of the Italian Institute of Technology in Genoa, he carried out the role of Health and Safety Officer, ISO:45001 auditor and trainer.
She graduated in 2014 in Biotechnology at the University of Siena, with an experimental thesis carried out at the Department of Physiology, on the analysis of the effects of new anti-proliferative compounds on Chronic Myeloid Leukemia cells. She continued her training for her Medical Biotechnology Master’s degree, holding a thesis internship in the laboratories of Pathological Anatomy, where she practiced an analysis on the variation of gene expression in Burkitt’s lymphoma. After obtaining her Master’s degree in 2016, she started an extracurricular internship at VisMederi, mainly dealing with the development and optimization of different cell cultures for the evaluation of immunological vaccine response. In March 2018, she began working at VisMederi Research where she continues to deal with the growth conditions of human and animal cell lines.
After obtaining her high school leaving qualification in Scientific and Technological Studies at the “Istituto di Istruzione Superiore Sarrocchi” of Siena, she chose to follow her passion by enrolling in the Chemistry and Pharmaceutical Technology Master’s course at the University of Siena in 2014. She then graduated in 2020, taking part into an experimental thesis project in Applied Biochemistry on the development of extracts with antioxidant activity. On that occasion, she was able to develop her skills on the management of laboratory procedures. She recently joined the VisMederi Research team.
Graduated with honors in Biology, she achieved a three-year degree in Biological Sciences in 2014 and a degree in Health Biology at the University of Siena in 2017. After a post-graduate internship at the Pharmacology Laboratories of Angiogenesis and Pharmacogenetics, she obtained a scholarship for research activities at the University of Siena in 2017. In these same laboratories, she continued the study of “Cellular and molecular mechanisms of Angiogenesis in the presence of compounds able to release Nitric Oxide”. This study led her to a publication on Biochemical Pharmacology in 2018. During her research grant, she carries on some teaching activity for the ITS New Technologies of Life Foundation, where she holds the role of Professor of the Microbiology course for the “PROBIT 2.0 – Higher Technician for the quality system of biotechnology-based products and processes” project. Since July 2018, she has joined the VisMederi Research’s team focusing on the development of different types of cell cultures and on serological test learning.
Francesca graduated in 2013 in Biological Sciences at the University of Bologna, with an experimental thesis on Medical Genetics. In 2016, at the same university, she graduated with honours in Pharmaceutical Biotechnology with an experimental thesis on Nanotechnologies, dealing with tetrahedral DNA nanostructures. Subsequently, she first obtained a scholarship at the Tuscan Tumour Institute in Siena and then a doctorate in Genetics, Oncology and Clinical Medicine at the University of Siena, working on orthotopic glioblastoma mouse models, confocal microscopy and cell biology. Since September 2020, she has joined the VisMederi’s Research team and she is working on the development of serological assays aimed at evaluating the immunogenicity of SARS-CoV-2 vaccines in clinical studies.
Donata graduated in Biotechnologies in 2014 at the University of Siena with an experimental thesis carried out at the Fondazione Umberto di Mario ONLUS, aimed at investigating the role of innate immunity in the pathogenesis of Type 1 Diabetes.
She continued her studies for a Master’s Degree in Medical Biotechnologies at the University of Siena with an experimental thesis focused on validation of Virus-Neutralization assays for the evaluation of seasonal influenza vaccine immunogenicity.
At the same time, she carried out an internship in VisMederi as a responsible for the autonomous management of cell culture facility and storage. Moreover, she was involved in both validation and performance of serological assays to assess the antibody response to vaccines in clinical trials following international guidelines (WHO, ICH, EMA, FDA).
Graduated in 2016, she immediately obtained a PhD position in Life Sciences at the University of Siena in collaboration with VisMederi, where she improved her experience in Applied and Developmental Research in the field of Public Health (within a certified quality system integrated with GLP and GCLP) by assessing different aspects of immune response to bacteria and virus infections and vaccines, both in clinical trial settings and in research contexts.
During her doctoral program, she spent four months at the Department of Molecular Virology of Universitair Medisch Centrum Groningen in the Netherlands as an Exchange PhD student.
Upon completion of her European Doctorate with excellence in 2019, she obtained a position as Junior Scientist in Vismederi Research. She is currently working on the development of serological assays aimed at evaluating the immunogenicity of SARS-CoV-2 vaccines in clinical studies.
Linda graduated in Biological Sciences at the University of Siena in 2012 with an experimental thesis on the involvement of TGF-β pathway in postnatal lung organogenesis. In 2015 she obtained a Master’s degree in Health Biology with a thesis on Glycodelin A glycoforms in human placenta, carried out at the Life Sciences Department of the University of Siena and, in the same year, she obtained the qualification to the profession of Biologist. In 2019 she obtained her PhD in Life Sciences, studying the effects of altered glucose metabolism and environmental chemical contaminants on foetal-placental development. She spent a period in Poland as a visiting PhD student, where she dealt with the set-up of protocols for 3D cell cultures at the Polish Academy of Science in Olsztyn. Linda has held the role of teacher of theoretical-practical lessons in Physiology and Cell Biological Laboratory Skills and has participated in international conferences and seminars as a speaker. Moreover, she obtained a research grant at the Department of Molecular and Developmental Medicine at the University of Siena. Linda has performed the role of Clinical Trial Assistant by participating in the SI-PHAR&D project promoted by the ITS Vita foundation. During this experience she had the opportunity to gain new skills in the design of clinical studies and development of new drugs and obtained the certification of Good Clinical Practices (GCP). In 2020 Linda has joined VisMederi Research, where she is currently dealing with the development of cell culture protocols for the research and development of new vaccines.
Virginia obtained her Bachelor’s degree in Biotechnology with honours at the University of Siena in September 2019. She carried out an internship of a couple of months at VisMederi Research that resulted in her experimental thesis entitled: “Evaluation of anti-influenza HA1 and HA2 antibodies in pre- and post- vaccination human serum samples, and correlation with hemagglutination inhibition results”. At the end of September 2019, she moved to London to obtain a Master’s degree in Biomedical Research at Imperial College London. Since April 2020, back to Siena following the spread of Covid-19 pandemic, she has also begun working as a Researcher at VisMederi Research. Within the company, she is currently responsible for the implementation of serological assays with the aim of testing the immunogenicity of influenza vaccinations and innovative research projects.
Eleonora graduated in Biological Sciences at the University of Siena. She obtained a Bachelor’s Degree (BSc) in 2006 and a Master’s Degree (MSc) in 2008 at the Department of Physiopathology, Experimental Medicine and Public Health under the mentorship of Prof. Emanuele Montomoli. She carried out epidemiological and virologic surveillance for Influenza viruses through isolation, identification and typing. She was also trained in performing serological assays such as Haemagglutination inhibition (HI) and Single Radial Haemolysis (SRH) to evaluate seasonal influenza vaccine immunogenicity. In July 2014 she successfully obtained a PhD from the University of Kent (United Kingdom) under the supervision of Dr. Nigel Temperton (Infectious Diseases Group). Her PhD project investigated the development of surface-engineered lentiviral vectors (pseudotypes) as surrogate antigens in downstream pseudotype-based neutralization assays to study serological profiles of viruses responsible of viral zoonosis and emerging diseases, particularly in the field of respiratory viruses such as Influenza A viruses (HPAI and LPAI) and Coronaviruses. During her PhD she also developed an extensive knowledge in cell cultures and molecular biology techniques.
Her first job experience started in 2014 as a Research Scientist within the Analytical Development Group at Kedrion BioPharma (Bolognana, Lucca) where she was involved in the optimization and validation of analytical methods for characterization of intravenous Immunoglobulins moving successively within the Chemical Quality Control at Kedrion IKOD (Siena).
After two years’ experience in Kedrion, she was hired by GlaxoSmithKline (GSK, Siena) within the Microbiological Quality Control Group.
Before joining the Vismederi Research Group in 2020, she spent one year at GSK Vaccine Institute for Global Health (GVGH) as a Scientific Associate within the Immunoassay Unit supporting the serological evaluation of GVGH vaccine projects (mainly on Shigella).
Filippo obtained his Bachelor’s Degree in Natural Sciences at the University of Siena in 2017, followed by an internship at the Residue Analysis Laboratory within the Department of the same University, where he developed a thesis about the levels of organochlorines detected in three different species of dolphins. Furthermore, he had the opportunity to strengthen this knowledge through his Master’s Degree in Ecotoxicology and Environmental Sustainability, which gave him the possibility to further investigate around ecotoxicological problems. In 2019, he published a thesis concerning the collection, recycling, disposal, toxicological effects and waste management of natural exhausted oils. He recently started an internship in VisMederi Research.
Graduated in 2017 in Biotechnology at the University of Siena, with an experimental thesis carried out at the Department of Microbiology on the study of the immunity response to vaccination through ELISA immunoenzymatic assays and multi-parametric cellular analysis through flow cytometry. She is pursuing with her Medical Biotechnology Master’s degree, carrying out her thesis internship in the VisMederi Research company. She is currently performing classic serology tests for antibody detection against influenza virus hemagglutinin, together with the development of competitive ELISA immunoassays for the discrimination of antibodies against influenza virus Stalk domain and type A immunoglobulins.